8/30/2023 0 Comments Low ag ratioThe rate of debilitating PJI following TJA is approximately 1–2.5%, imposing a huge burden on the individuals and health care system. However, subsequent complications, especially the periprosthetic joint infection (PJI), have been increasingly recorded over decades. Total joint arthroplasty (TJA) is a successful surgery to relieve pain and improve the quality of life. Conclusionsīoth globulin and A/G ratio were associated with PJI and may serve as potential adjuvant biomarkers in the diagnosis of PJI. ROC curve analysis demonstrated reasonable diagnostic performance for globulin (area under the curve, 0.77 sensitivity, 78.95% and specificity, 69.66%) and A/G ratio (AUC, 0.779 sensitivity, 65.79% and specificity, 78.65%). Higher globulin levels (odds ratio, 1.239 P < 0.001) and lower A/G ratio (OR, 0.007 P < 0.001) were strongly associated with the risk of PJI. The diagnostic performance of these proteins was assessed by the receiver operating characteristic (ROC) curve. The serum proteins were explored using univariate analysis followed by multivariate logistic regression. ![]() MethodsĪ retrospective study was conducted on patients who had undergone revision TJA between 20 (89 with aseptic mechanic failure and 38 with PJI). ![]() ![]() We aimed to evaluate the relationship between globulin, albumin to globulin (A/G) ratio, and development of PJI in patients undergoing revision total joint arthroplasty (TJA). Furthermore, there is a dire need to identify appropriate and effective biomarkers. Periprosthetic joint infection (PJI) has been increasingly documented however, its preoperative accurate diagnosis remains challenging.
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